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Impeded mRNA synthesis contributes to the effectiveness of pan-CDK inhibitors. C can function as a bona fide oncogene. Oncogenic functions of CDK8 are related to the modulation of transcription programs. CycC among other CDKs enables SBDD of selective inhibitors. C inhibitors are currently in preclinical development. This review is focused on the key biological roles of CDK8 kinase, which provide a proof-of-principle for continued efforts toward effective cancer treatment, targeting activity of this CDK family member. Among currently identified kinase inhibitors, several displayed significant selectivity for CDK8 and notably the effectiveness in targeting cancer specific gene expression programs.
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